In 54 A.D., Scribonius Largus--physician to the Roman Emperor Claudius--recommended the use of cantherides to cause blistering and scarring as a method of tattoo removal.
Fortunately, we've come a long way since then.
Source: van Gulik WR. Irezumi: the pattern of dermatography in Japan. Rijksmuseum Voor Volkenkunde, Leiden, The Netherlands: E.J. Brill, p30 (1982).
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